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& Costello, R

[9] [10] Seek prompt medical attention if you experience: Severe or persistent abdominal pain, particularly radiating to the back (possible pancreatitis) Rapid or irregular heartbeat Signs of a severe allergic reaction including swelling of the face, lips, or throat, or difficulty breathing call 999 or attend your nearest A&E immediately Symptoms of significant dehydration (dizziness, reduced urine output) due to persistent vomiting or diarrhoea Symptoms of hypoglycaemia if taking concomitant insulin or sulphonylureas Anyone experiencing unexpected symptoms whilst participating in a clinical trial should contact their trial investigator or GP without delay

doi: 10.1016/S0140-6736(22)01429-5 69 Vernaza-TrujilloDABautistaLYREspinosaCMRCastilloSCorredor-RengifoDAristizabal-ColoradoDet al

Chronic cortisol elevation interferes with sleep architecture, promotes visceral fat storage, accelerates muscle breakdown, and impairs immune function

Harashima SI, Inagaki N, Kondo K, Maruyama N, Otsuka M, Kawaguchi Y, et al