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namely, 15-R epi-lipoxin A4 (lipoxin A4 or ATL), a metabolite of arachidonic acid (Romano et al., In operant self-administration studies, the presentation of a stimulus previously associated with alcohol self-administration leads to marked increases in glutamate release in nucleus accumbens (Gass et al., In the present studies, we investigated whether a reduction of ethanol intake induced by NAC follows the activation of the hippocampal Nrf2-ARE antioxidant signaling pathway, which could be prevented by inhibition of the xCT cystine-glutamate transporter and by inhibition of the glutamate presynaptic metabotropic mGlu2/3 receptor
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These medications, combined with behavioral therapy, are proven effective for alcohol addiction treatment