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Acetylcholine (ACh) and gastrin also contribute to gastric acid production but not to the degree of histamine
Zheng RH, Bai XJ, Zhang WW, Wang J, Bai F, Yan CP, James EA, Bose HS, Wang NP, Zhao ZQ
M., Liu, W., Zhang, X
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Contact your GP promptly if: Your allergy symptoms are not controlled despite using antihistamines or nasal corticosteroids as directed You experience swelling of the lips, tongue, or throat (angioedema) seek urgent medical assessment, as some forms of angioedema (such as that caused by ACE inhibitor medicines or hereditary angioedema) are not histaminergic and require different, specialist treatment You are taking an ACE inhibitor (e.g., ramipril, lisinopril) and develop angioedema stop the medicine and seek urgent medical review You are taking prednisolone and notice significant side effects such as severe mood changes, signs of infection, or markedly raised blood sugar You are unsure whether it is safe to stop your steroid course In an emergency if you or someone else develops signs of anaphylaxis (widespread rash, breathing difficulties, swelling of the throat, feeling faint or losing consciousness): Use an adrenaline auto-injector (e.g., EpiPen) immediately if one is available Call 999 Lie flat with legs raised (or sit upright if breathing is difficult) Adrenaline is the first-line treatment for anaphylaxis (Resuscitation Council UK, 2021
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