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Easily oxidized, this -SH group readily interacts with reactive oxygen species (involved in oxidative stress), but also with many other compounds with which it is capable of forming disulfide bridges (bonds between two sulfur atoms)
However, donors must be adequately hydrated beforehand and should have eaten normally
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Clinical trial data from the NEJM Phase 2 study showed that gastrointestinal events were predominantly mild to moderate, occurred primarily during dose escalation, and were partially mitigated by starting at 2mg rather than 4mg
It was approved by the EMA for type 2 diabetes (T2D) in July 2009 and it was approved by the FDA for T2D in January 2010
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