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Persistent redness, cracking, itching, or irritation should be evaluated by a healthcare professional

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The treatment reduced periorbital wrinkles by 55%, outperforming placebo and vitamin K cream, with 70% of participants reporting improved firmness and clarity (Abdulghani et al., 1998)

Localized allergic signs include injection site reactions that worsen with each successive dose rather than improving over time, spreading hives (urticaria) extending well beyond the injection site, and severe swelling (angioedema) at the injection site that does not resolve within 48 hours

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