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Results Study Selection and Characteristics A total of 23 phase III randomized controlled trials met the inclusion criteria, contributing 48 treatment arms conducted exclusively in individuals with T2DM (see Table 1 for a summary of trial-level and treatment-arm characteristics, and Supplementary Table S1 for detailed study characteristics)

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however, a potential efficacy was observed with lower LVEF and declining efficacy with increasing LVEF

~41% dermis) and improved hydration (+12%), firmness (+29%), elasticity (+20%) after 56 days

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