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Certain conditions can make its use unsafe or inappropriate: Personal or Family History of Medullary Thyroid Carcinoma (MTC): Due to the observed risk of thyroid C-cell tumors in rodent studies, individuals with this history should avoid semaglutide
By targeting both GLP-1 and GIP receptors, Tirzepatide has the potential to more effectively address multiple aspects of metabolic syndrome than single-target therapies, making it a promising option for MASH treatment2
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The starter dose is 1.5 mg
However, not all studies were included in each analysis due to lack of reporting on all outcomes by each individual study (see Supplementary Material Tables S5S7)
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