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Neither creatine nor carnitine have been shown to affect sleep, although some studies suggest that creatine can help maintain mental performance after inadequate rest
Some users report improved exercise endurance and reduced mental fatigue during workouts
Poor Hydration Dehydration can worsen constipation, nausea, fatigue, and digestive discomfort
The earliest realistic timeline for UK availability is 2028 or later, following anticipated phase 3 data in 20252026, a potential MHRA submission in 20262027, and subsequent NICE appraisal
The guidance emphasizes shared decision-making among the patient, proceduralist, anesthesiologist, and prescribing clinician
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