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Accordingly, we encourage the adoption of GLP-1RA plus SGLT2i combination therapy in patients with T2DM and established atherosclerotic cardiovascular disease (ASCVD) or multiple risk factors for ASCVD (i.e., age 55 years, overweight/obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria)
(2020) 79(OCE2), E245
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-15.2% versus -2.6% and plateau around week 60
Contraindications include increased bleeding, a history of medication hypersensitivity, lumbar puncture, and spinal anesthesia (10)
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