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LA maintains the cellular antioxidant state indirectly through activating the NRF2 pathway, and the NRF2 pathway governs the expression of antioxidant genes (such as -glutamylcysteine synthetase (-GCL), NAD(P)H quinone oxidoreductase 1 (NQO-1), and superoxide dismutase (SOD)) for enhancing the cell's antioxidant capacity and anti-inflammatory response [34, 35]
A key gene called AIRE (autoimmune regulator) plays a critical role in thymic selection
Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinsons disease
G.KaiserB.WangX.ThieleJ
There are some reports of acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing variants but it remains unproven till now and not observed in post market surveillance
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