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CR3 was initially anticipated to be the main (1,3)- - glucan receptor on leukocytes but the ability of CR3-deficient leukocytes to still reckon and respond to (1,3)- - glucans and the discovery of Dectin-1 suggests that CR3 may only display a minor role for macrophage and dendritic cells (reference herein)
Tsai M, Huang Y, Fang J, Fu Y, Wu P
EVs derived from resting neutrophils have been shown to have an anti-inflammatory effect on the surrounding immune cells
It also helps the skins cellular "factories" (called fibroblasts) work more effectively and can even encourage skin stem cells to become more active
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