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acknowledges support from the NIH/NCI (R01 CA216273, U10 CA180861) and from the CLL Global Foundation, and is a member of the Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute, whose work is supported, in part, by the Parker Institute for Cancer Immunotherapy

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Ten-eleven Translocation (TET) enzymes converts methylcytosine (m 5 C) to hydroxymethylcytosine (hmC), which is not recognized by Dnmt1, it is believed to exclude maintenance methylation allowing for passive demethylation, and it is an intermediate in the active conversion of m 5 C to cytosine (C) 27

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