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This article examines the potential of GLP-1 RAs in MASH treatment, exploring their mechanisms of action, clinical benefits, developmental challenges, and evaluation strategies in preclinical MASH models
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Most side effects improve substantially within 4-8 weeks of starting treatment or after each dose increase, and many patients find that the benefits of improved glycemic control and weight loss outweigh the temporary discomfort of initial side effects
If you haven't started tirzepatide yet but have a history of pancreatitis, gallstones, or heavy alcohol consumption, bring it up with your healthcare provider before your first dose
This warning states that tirzepatide causes thyroid C-cell tumors at clinically relevant exposures in rodents, and that it is unknown whether tirzepatide causes thyroid C-cell tumors, including medullary thyroid carcinoma, in humans
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