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Higher doses produce greater weight reduction, but with diminishing returns and increasing side effects

instead, you prevent weight regain by preventing tolerance

In 2021, semaglutide was FDA-approved for chronic weight management in those with obesity or overweight under the brand name Wegovy

Though exact dosing for retatrutide in the weight-loss setting is still being defined (because many of the uses remain investigational), in the key trial adults with obesity treated weekly showed large body weight reductions: e.g., up to ~17.5% at 24 weeks and up to ~24% at 48 weeks in certain dose groups

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