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Before starting the therapy, the patients are screened to determine possible contraindications according to the medical history and existing medications

However, after prostate cancer treatment, erectile dysfunction is often neurogenic or multifactorial, involving: Nerve injury from surgery Reduced nitric oxide signaling Hormonal suppression from androgen deprivation therapy Psychological stress and performance anxiety Most importantly, PDE5 inhibitors require an existing sexual signal from the brain to work effectively

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Patients who had severe nausea on semaglutide may still have nausea on tirzepatide, but it's likely to be modestly less severe at equivalent weight-loss doses