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[6] [7] These gastrointestinal effects result from the medications' impact on gastric motility and are generally most pronounced during dose escalation, often improving with continued therapy as tolerance develops

In a human Phase I study, subcutaneous MT-II increased skin pigmentation (measured by quantitative reflectance) after only a few low doses, alongside central melanocortin effects[1]

Howard AD, Feighner SD, Cully DF, et al

Understanding these factors is important for identifying and addressing the underlying causes of carpal tunnel syndrome, facilitating effective treatment and prevention

These symptoms typically diminish over several weeks as tolerance develops