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In the STEP-1 obesity trial, semaglutide 2.4 mg weekly produced roughly 14.9% mean body-weight loss over 68 weeks ( Wilding et al., NEJM 2021 )
These are usually most noticeable early on in treatment or after dose increases and tend to improve as the body adapts to the medication
This implies that it is going to burn fewer calories to defend itself
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Qsymia: A combination of phentermine and topiramate that reduces appetite and creates a feeling of fullness
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