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THE SURMOUNT PHASE 3 CLINICAL TRIAL PROGRAMME Key clinical trial results SURMOUNT-1: Significant weight loss vs placebo in obesity Tirzepatide produced significant and substantial weight loss in adults with obesity or overweight (without diabetes) compared with placebo over ~72 weeks, with up to 22.5% average reduction in body weight at higher doses plus improvements in key weight-loss thresholds

In rats and mice exposed to semaglutide at clinically relevant doses, researchers observed C-cell adenomas and carcinomas at statistically significant rates compared to control animals

a slight stinging sensation may be experienced due to the compound's quinolinium structure

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