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To rule out inferiority, the FDA required CVOTs to show an upper boundary risk ratio of 1.3 (post approval), utilizing a two-sided 95% confidence interval (CI), for major adverse cardiovascular events (MACE) [55]
10.1038/ijo.2013.149 76 le RouxC
Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment
However, while taking semaglutide, if you experience symptoms of pancreatitis, such as sudden, severe pain in the abdomen that radiates to the back, nausea, fever, or vomiting, discontinue the medication immediately and consult your doctor
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