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When the average tumor volume reached 200 mm 3 (in about 23 weeks) mice were randomized to two treatment groups, one group was fed with a methionine deficient diet containing 0.172% DL-methionine (cystine-free) and the other group was fed with a control diet containing 0.86% DL-methionine (cystine-free) ad libitum with free access to water
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Pharmacokinetic characterisation is comparatively thin, but distribution and elimination have been profiled in rats and dogs in a 2023 pharmacokinetic study (PMC9794587), which is useful context because most claims about systemic healing rest on animal exposure data rather than validated human pharmacology
Sci Rep 6:35539
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