PMID: 36 ZhengZZongYMaYTianYPangYZhangCet al
Improve blood sugar control and reduce the risk of complications related to diabetes
First, the number of direct active-comparator trials remains small, and many complication-specific analyses are informed by single trials or by a small number of dedicated studies rather than by dense evidence networks
At first, Wegovy was FDA-approved for chronic weight management when paired with exercise, dietary modifications, and increased physical activity in patients with obesity (body mass index 30 kg/m or more) and overweight (BMI 27 kg/m or more) with at least one weight-related health condition such as heart diseases, high blood pressure (hypertension), high cholesterol levels, type 2 diabetes, and sleep apnea
Interestingly, these residues of the GLP-1R are crucial for intracellular signaling and are responsible for insulin exocytosis