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Yet a major obstacle remains: cost
The tert-butyl moiety of compound 2 points to TM7 and makes hydrophobic contacts with A350 6.39b and K351 6.40b , replacement at C-3 position by polar functional groups caused dramatic decline in its potency and efficacy 38
Biomarker-focused assays : Incorporated into experiments tracking GH-axisassociated markers under controlled conditions (endpoint-dependent)
Hartman calls a paradoxical reaction
Although no significant differences were found among the groups in total hip and femoral neck aBMD or trabecular bone score (TBS), changes in lumbar spine aBMD approached statistical significance
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