GSH in fact is both a nucleophile and a reductant, and therefore can react with electrophilic or oxidizing species rendering the former molecules more soluble and excretable, and the latter unable to interact with more critical cellular constituents such as lipids, nucleic acids and proteins
The study suggests that GLP-1s "have a key role in kidney-protective and heart-protective treatment for patients with common medical conditions like Type 2 diabetes, overweight or obesity with cardiovascular disease, or chronic kidney disease," he said in a news release
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This flexibility may be especially important for adolescents where there is a major need for safe pharmacology treatments, noted Andrew Hogan, PhD, who is an associate professor of immunology at Irelands Maynooth University, and also not involved in the study