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Patients with pre-existing diabetic retinopathy should be monitored closely, especially if on insulin, due to the risk of transient worsening with rapid glycaemic improvement

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To dissect the role of caspases in the observed profile, we included two inhibitors: Q-VD-OPh (referred to hereafter as QVD), a pan-caspase inhibitor targeting caspases 1, 3, 7, 8, 9, 10 and 12, and Ac-DEVD-CHO (referred to hereafter as DEVD), which selectively inhibits caspases 3, 6, 7, 8 and 10

The immune system shifts dramatically toward Th2 dominance, flooding the skin with interleukin-4 (IL-4), interleukin-13 (IL-13), and interleukin-31 (IL-31)

NICE NG28 recommends DPP-4 inhibitors as add-on therapy in type 2 diabetes management, or as an alternative first-line option if metformin is contraindicated or not tolerated