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Aerobic Capacity Research published in Medicine & Science in Sports & Exercise found no significant improvement in VO2 max or exercise performance with L-carnitine supplementation in trained athletes, raising questions about its efficacy for endurance

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Some improvements were noted in specific symptoms for female participants, particularly in reducing thirst and fatigue, but these effects were not significant across the broader participant group

Patients initiating GLP-1 therapies had many other targetable comorbidities at baseline, and patients who had a higher rate of comorbidities at baseline tended to stay on GLP-1s longer