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Funding This work was supported by grants from the Natural Science Foundation of Guangdong Province (2018A030313846 and 2021A1515012593), the Science and Technology Planning Project of Guangdong Province (2019A030317020), the National Natural Science Foundation of China (81802257, 81871859, 81772457, 82172750, 82172811, and 82260546), the Guangdong Basic and Applied Basic Research Foundation (GuangdongGuangzhou Joint Funds) (2022A1515111212), and the Science and Technology Program of Guangzhou (2023A04J1257)
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Jias team have demonstrated targeted accumulation capability in arthritis models, which can reduce systemic toxicity and enhance therapeutic efficacy (Wang et al., 2020)
Human Safety Data: The Small Available Dataset The PL 14736 inflammatory bowel disease trials referenced in Sikiric (PMID 21548867) tested oral BPC-157 at clinical doses
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