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In CKD patients, even though anemia develops primarily as a result of the decreased lifespan of RBCs caused by the low production of erythropoietin and iron deficiency, eryptosis seems to be a fundamental contributing factor [244,245,246]

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There are multiple common polymorphisms(genetic differences) that can lead to this outcome

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Mitochondrial modulations, autophagy pathways shifts in viral infections: consequences of COVID-19