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This clinical improvement was corroborated by a marked reduction in interleukin-6 (IL-6) concentrations, decreased expression of TNF- and the NF-B p65 subunit, and the normalization of other key inflammatory biomarkers (255)

Placebo-adjusted value or actual measured value from baseline

Design, synthesis, and biological evaluation of long-acting glucagon-like peptide-1 (GLP-1) conjugates modified with dual fatty acids and a proline-alanine-serine (PAS) polypeptide

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Their action significantly reduced 4-HNE levels in renal tissue, with Fe and MDA levels decreasing by 38% and 42%, respectively, significantly alleviating damage to renal tubular epithelial cells and improving renal function indicators such as serum creatinine and blood urea nitrogen [63]