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Once iron reaches the brain's interstitium, it is oxidized to a safer Fe 3+ form by hephestin or ceruloplasmin and incorporated into transferrin for uptake by neurons and glia (Chen et al

) Method for preparing in vivo formulation: Take L DMSO master liquid, next addL PEG300, mix and clarify, next addL Tween 80, mix and clarify, next add L saline, mix and clarify

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