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It reduces blood glucose levels and stimulates GLP-1 secretion via a G-protein mediated pathway, while also enhancing the insulin secretion through the modulation of ATP-dependent potassium channel thereby increasing calcium influx from intracellular reserves
Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain
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Subsequent progenies were generated by mating Gipr fl/fl male mice (no synapsin-Cre) with female homozygous floxed Gipr mice with the synapsin-Cre transgene ( Gipr Syn/ ) to produce mice with CNS KO of Gipr ( Gipr Syn/ )
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