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Statements Acknowledgments This work was supported by the Ministerium fr Wissenschaft und Forschung des Landes Nordrhein-Westfalen (Ministry of Science and Research of the State of North Rhine-Westphalia), and the Bundesministerium fr Gesundheit (Federal Ministry of Health)

The cause of this translational failure is largely due to the use of imprecise models, and its cumulative effect is substantial