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The hepatic metabolism pathway for BPC-157 means the peptide passes through the liver where many medications are also processed
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(Frontiers in Nutrition, 2026 review)
A subsequent 2014 paper by Chang and colleagues in Molecules showed that BPC-157, applied at 0.10.5 g/mL in vitro, dose- and time-dependently upregulated growth hormone receptor expression at both mRNA and protein levels in cultured rat Achilles tendon fibroblasts a mechanistic in vitro finding for which numeric fold-changes and p-values are not reported in the abstract
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