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The FDA has flagged BPC-157 because of risks like immunogenicity (it could trigger immune reactions), peptide impurities, and lack of human safety data
TB-500 operates primarily through actin dynamics: it binds G-actin monomers to regulate the monomeric actin pool, which is thought to influence cell migration in experimental wound models
HG also induced epithelial-mesenchymal transition (EMT) and upregulated fibrosis-related genes, suggesting that HG-induced EMT contributes to subretinal fibrosis, the end-stage of eye diseases, including proliferative DR
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