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I've been on it for a year, and I've lost about 70 pounds
Regular lipid panel monitoring helps track your response and guide any dose adjustments
40 ClinicalTrials.gov NCT04067999
In a phase 2 trial, tirzepatide (GLP-1 RA/GIP agonist) demonstrated 56%-62% achieving resolution of MASH and 51% achieving at least 1 stage of fibrosis compared to 10% MASH resolution and 30% fibrosis improvement in those on placebo [8]
A further dimension emerged in May 2026, when the ATTAIN-MAINTAIN trial, published in Nature Medicine , found that patients who switched to orforglipron after achieving substantial weight loss on injectable GLP-1s maintained approximately 7580% of that weight reduction
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