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NO production is known to decrease with aging primarily via decrements in the NOS-dependent pathway (Pourbagher-Shahri et al., 2021

It also reduces the appearance of dark spots and hyperpigmentation

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Patients with severe heart failure or arrhythmias require monitoring because rapid shifts in free-fatty-acid metabolism can influence myocardial substrate utilization

Our findings extend the therapeutic rationale for semaglutide in PCOS beyond metabolic benefits, suggesting potential direct ovarian protection via epigenetic modulation