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8 Reasons for less weight loss with GLP1 RAs for T2D could include use of insulin or other obesity-promoting medications, concerns over hypoglycemia, decreased glycosuria, microbiome variation, genetic predisposition towards weight gain, and differences in endogenous GLP-1 pathways in the brain and other tissues
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The Power of Combination: The S-LiTE Trial Research published in JAMA Network Open (Sandsdal et al., 2023) and The Lancet Healthy Longevity (Jensen et al., 2026) compared GLP-1 use alone versus GLP-1 plus exercise: Body Composition: The "Exercise + GLP-1" group reduced abdominal fat by 6.1% , nearly double the results of the medication-only group
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