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PAHs are known to induce severe redox stress in cells and tissues, leading to the oxidation of nucleic acids, proteins, and lipids ( As expected, testis samples from exposed animals showed activation of DNA repair machinery, including the 8-oxoguanine glycosylase (OGG1), a base excision repair enzyme responsible for the recognition and removal of 8-OHdG, histone H2A variant, H2AX and PARP-1
Proprits Le glutathion est la base de notre systme immunitaire
Perhaps not a problem
When there is not enough glutathione to eliminate the toxins they start to stack up in the liver and cause mitochondrial damage your cells energy powerhouse affecting glutathione production
To consolidate these design-function relationships across biomedical contexts, Figure 7 provides a schematic overview of representative precursors and engineering strategies discussed in this section
