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Effect of tamoxifen on cell lines displaying the multidrug-resistant phenotype
The compounds with lower potencies 2 (2%) and 16 (0.4%) showed no effect after 30 min and were therefore less effective than peptide 1 (100%), although 16 had longer half-life in plasma (16 vs 38 min)
894 Acid sphingomyelinase (ASM)-mediated autophagy activation is critical for hyperglycemia -induced GPX4 degradation, and inhibition of ASM improves osteogenic function by reducing hyperglycemia-induced GPX4 degradation and subsequent ferroptosis
These reagents were added either in Cys 2 -free culture medium or coincubated with BSO or erastin at indicated concentrations
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