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If you want a fuller breakdown of how this class works, our article on what the GLP-1 hormone does is a helpful place to start

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Weight loss is complex, and even with powerful tools like Semaglutide, factors like dosing, hormones, stress, nutrition, muscle mass, and underlying conditions all play a role

Metformin contraindications include type 1 diabetes, kidney dysfunction, congestive heart failure that requires drug treatment, hypersensitivity to metformin, acute or chronic metabolic acidosis, and impaired liver function

Mounjaro came first and is FDA-approved : To treat type 2 diabetes in adults by controlling their blood sugar levels Zepbound is FDA-approved : For chronic weight management in adults with obesity or overweight and a weight-related medical condition To treat obstructive sleep apnea in adults with obesity Prior to Zepbounds approval, healthcare providers may have been more likely to prescribe Mounjaro off-label for weight loss to patients with overweight or obesity who may not have had type 2 diabetes