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GLP-1 signaling also modulates dopamine-related reward circuits, which can dampen food-driven behaviors in research animals
Pathogenic variants in the SLC25A19 gene result in microcephaly, Amish type
22 In addition to the mentioned effects, could GLP-1 RAs treat PCOS through other mechanisms
Consistent with the observation that glucagon acts on the pancreatic -cells to stimulate insulin secretion via the GLP-1 receptor (GLP-1R) [24,25,26,27], long-term treatment of diet-induced obese (DIO) mice with a biochemically modified water-soluble glucagon improved glucose metabolism with equal efficacy relative to treatment with exendin-4 [23]
