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Notably, the effect of CR and DL feeding on Cysteine and Methionine metabolism was observed in both plasma and brain samples of female, but not male, 3xTg mice, with similar effects on most of the metabolites detected despite the pathway being upregulated in the brain and downregulated in the plasma (Fig
Zhang, S., & Baker, M
These limitations are further compounded by the lack of therapies for early disease stages, where neuroprotection or vascular stabilization could halt progression
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