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By binding to the GHRH receptor on the anterior pituitary, it initiates a release of growth hormone that preserves the natural negative feedback loops, preventing the saturation of receptors often seen with long-acting analogs
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We acknowledged this as a limitation of the study and are aware that it may affect the interpretation of the results
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In fact, these anti-inflammatory effects have been demonstrated in mouse microglia, macrophages, monocytes, and astrocytes (Kobayashi et al., 2016
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