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*Correspondence: Jose Echenique, [email protected] These authors have contributed equally to this work and the order of these authors is arbitrary Present addresses: German E

Berberine is an alkaloid found in the roots, bark, and other structures of many plants, including the Oregon grape ( Mahonia aquifolium ), goldenseal ( Hydrastis canadensis ), Indian barberry ( Berberis aristata ), and European barberry ( Berberis vulgaris )

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The broader rationale is the copper-tripeptide class

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