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In particular, heart mitochondria from mice with selective TSPO deletion in hearts undergo MPT and are as sensitive to ischemiareperfusion injury as hearts from control mice

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557 Stimulation of TLR5 through mucosal administration of a flagellin-fused protein has been shown to effectively extend the lifespan and enhance the health span of mice of both genders

Despite its documented efficacy in vitro and in vivo in alleviating oxidative stress and preventing iron deficiency, Fer-1 remains untested in clinical trials (114)