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Retatrutide, a triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors, is currently in late-stage clinical trials and showing even greater weight loss results than its predecessors
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However, some weight regain (25-50% of lost weight) may occur over 1-2 years if lifestyle behaviors return to pre-treatment patterns
And tirzepatide itself has demonstrated significant improvements in metabolic parameters beyond weight loss, so finding an alternative that matches its metabolic profile is challenging
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