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The incidence of reported hypoglycemia was higher with pioglitazone 45 mg compared to pioglitazone 30 mg in both the 24-week add-on to sulfonylurea trial (15.7% versus 13.4%) and in the 24 week add-on to insulin trial (47.8% versus 43.5%)
Pharmacol Rep 68(2):329337 Chen J, Mei A, Liu X, Braunstein Z, Wei Y, Wang B et al (2022) Glucagon-Like Peptide-1 receptor regulates macrophage migration in monosodium Urate-Induced peritoneal inflammation
Its dosed weekly and used primarily for managing Type 2 diabetes, although its often prescribed off-label for weight loss. Wegovy costs around $1,300 per package out-of-pocket
GLP-1 and GIP are naturally occurring gut hormones involved in blood sugar regulation, appetite signaling, and other metabolic processes
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