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When this control is changed by oxidative or electrophilic signals, Nrf2 can accumulate and increase the expression of antioxidant-response genes, including those involved in GSH synthesis
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It is also called a master antioxidant because it exerts its effects within cells and its unique ability to maximize the effects of all other antioxidants, including vitamins C and E, Q + Ubiquinol, r-alpha-lipoic acid
In these cases, a lower-dose approach may allow partial receptor engagement while clinicians monitor symptoms and metabolic markers
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