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Melanotan-2 binds to melanocortin-1 receptors (MC1R) on melanocytes in the basal epidermis, triggering a cAMP-mediated signaling cascade that activates microphthalmia-associated transcription factor (MITF)
Complete loss of lag-1 results in L1 larval lethality, reflecting LAG-1 functioning as the DNA binding co-factor for both GLP-1(ICD) and LIN-12(ICD), while a lag-1 hypomorphic mutant results in incompletely penetrant loss of germline stem cells due to premature entry into meiotic prophase [11,17]
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Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 149 , 112918
Cell kill kinetics of chemotherapy
