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Oral route data in rodents shows genuine GI-local effects, but systemic bioavailability from capsules is unquantified in humans, meaning dose-response claims for joints and tendons rely on injection-route animal studies
Some individuals report that late-day injections interfere with sleep, possibly through nitric oxide system activation
The timing of GLP-1 administration may influence the tolerability of these symptoms, though this has not been definitively established in clinical trials
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