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Nanoscale Res Lett

A baseline reading was recorded for 1 minute followed by stimulation with 1 M exendin-4 in 6 mM glucose KRBH for 2 minutes

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Therefore, multi-targeting or unimolecular peptides possessing combinatorial agonism at GIPR, GLP-1R and GCGR have been extensively explored and more than a dozen peptides including two GIPR/GLP-1R dual agonists, ten GLP-1R/GCGR dual agonists and five GIPR/GLP-1R/GCGR triagonists have entered into clinical development (Supplementary Fig